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Blood glucose (also called blood sugar) is a primary marker for determining diabetes risk. The higher your blood sugar, the higher your risk. But blood-sugar is not just a marker for diabetes. As blood-glucose levels rise, so does the risk for many other life-threatening conditions, most notably heart disease.

The best way to mitigate your risk is to keep your blood sugar at healthy levels. What level is that, you wonder? The answer is controversial. The American Diabetes Association (ADA) delineates certain levels as “normal,” but the ADA’s “normal” may not mean “optimal”.  

What’s more, measuring blood glucose isn’t the only (or even the best) way to assess metabolic health (ideal levels of blood sugar, triglycerides, high-density lipoprotein (HDL) cholesterol, blood pressure, and waist circumference; more on this later.) This article helps to clarify things. You’ll learn all about blood glucose: the basics, measurement, management, and what levels are considered healthy.

What Is Blood Glucose?

Glucose, as you’re probably aware, is a form of sugar. Alternatively, you can call glucose by its other, more polysyllabic name: carbohydrate. Yes, when you eat starchy carbs or sugar, you’re eating glucose. Then that glucose passes through your gut and into your bloodstream. 

Blood glucose, then, simply refers to sugar molecules (C6 H12 O6) floating around in your veins and arteries. 

Blood glucose is necessary for survival. Your red blood cells, for example, can’t use any other fuel. Your brain also sucks up glucose like a vacuum cleaner—about 120 grams per day. (Only 30 grams per day if it’s in ketosis, though).

Carbs, however, are not necessary for survival. When glucose is scarce (on a fast, for instance), your blood sugar doesn’t go to zero. Instead, to keep glucose levels up, your body activates two glucose backup mechanisms:

  1. Glycogenolysis: The release of stored glucose from muscle and liver cells. (You store about 500 grams of glucose as glycogen).
  2. Gluconeogenesis: When glycogen becomes depleted, your liver makes glucose from protein and lactate. Cool survival mechanism.  (Learn more about gluconeogenesis here.)

But in obese and diabetic populations, glucose isn’t scarce. Rather, there’s too much of it.  

Blood Sugar, Insulin Resistance, and Disease

Since the 1950s, US diabetes rates have increased more than sevenfold. Driving this epidemic is a dramatic increase in sugar consumption. 

It’s a bit more nuanced, however, than more dietary sugar = high blood sugar = diabetes. We need to talk about insulin. 

You see, when you eat a meal, your blood sugar rises, and the hormone, insulin, comes along to move that blood sugar out of your blood and safely into cells. Like a good blood-sugar boss, insulin keeps your blood vessels safe from the dangers of hyperglycemia. 

But when sugar consistently enters the body (think daily Big Gulps), the boss gets overworked. And when the boss gets overworked, it can’t do its job anymore. 

This is called insulin resistance – the inability of insulin to effectively store blood sugar in muscle and liver cells. In a state of insulin resistance, blood sugar stays too high for too long. This is how Type 2 Diabetes starts. 

In addition to diabetes, insulin resistance underlies many other chronic diseases: heart disease, cancer, Alzheimer’s, you name it. In fact, some researchers now view Alzheimer’s as a case of insulin resistance in the brain. 

Later, you’ll learn strategies for preventing insulin resistance. But first, a word on measurement. 

How To Measure Blood Glucose

To quantify your metabolic health, you’ll need to measure blood glucose levels. Common tests include:

    • Hemoglobin A1c (HbA1c): Provides a rough “average blood glucose” estimate of the past 2-3 months by measuring the amount of sugar stored in red blood cells.
    • OGTT: The oral glucose tolerance test (OGTT), administered in a lab, involves ingesting a sugary solution and measuring its impact on blood sugar levels
    • Fasting blood glucose: Your blood glucose after an overnight fast of around 12 hours.
    • Postprandial blood glucose: This is your post-meal blood glucose. It peaks 1 to 1.5 hours after eating. 

Both fasting and postprandial blood glucose are simple home tests, provided you have a glucose meter. Just prick your finger, insert the test strip, and record your result. If you have a Keto-Mojo blood glucose and ketone meter you can track your results over time with the free app.

Testing blood sugar is an ideal way to learn the effects of different foods on your body. Simply take a baseline reading (at least 3 hours after your last meal), eat a particular food, then test 1 or 2 hours after eating. You might be surprised which foods spike (or don’t spike) your blood sugar. See this guide to testing for your bio-individuality and learn which foods elevate your glucose levels so you can avoid them.  

What Should Your Blood Glucose Be?

Glucose Levels Chart

That is the question, isn’t it? To start, here’s how the ADA classifies diabetes risk for “fasting blood glucose (FBG) and HbA1c”

    • Normal: FBG under 100 mg/dl (5.6 mmol/L), HbA1c under 5.7 percent
    • Prediabetes: FBG from 100 to 125 mg/dl (5.6 to 6.9 mmol/L), HbA1c from 5.7 percent to 6.5 percent
    • Diabetes: FBG over 125 mg/dl (6.9 mmol/L), HbA1c 6.5 percent or above

But “normal” doesn’t necessarily mean “optimal.” Case in point: A large observational study following 46,578 non-diabetics over seven years found that those with FBGs from 95 to 99 mg/dl (5.3 to 5.5 mmol/L) – considered normal – were 2.33 times more likely to develop diabetes than those with FBGs below 85 mg/dl (4.7 mmol/L.)

So for fasting blood glucose, somewhere south of 85 mg/dl (4.7 mmol/L)seems best. But what about after eating?

As a general rule: the smaller and shorter the spike in blood sugar, the better. Practically, try to keep blood sugar spikes to under 30 mg/dl over baseline at one-hour post-meal. (If your baseline is 85 mg/dl (4.7 mmol/L), you don’t want to exceed 115 mg/dl. (6.4 mmol/L)) And by three hours after eating, you should be back near your baseline. This indicates that insulin—your blood-sugar boss—is doing its job. 

A quick caveat on fasting and postprandial blood glucose measurements: They’re not the most reliable measures of metabolic health. Stress, for instance, can cause the liver to dump significant glucose into the bloodstream—so if you’re nervous before the test, it could throw off the results. A poor night of sleep could have a similar effect. And then there’s the “dawn effect“, a natural release of cortisol in the early hours of the morning – which elevates glucose – to help your body get ready for rising. So it’s best to wait an hour or more after waking to take your fasting blood glucose, and longer for people with insulin resistance.

That’s why, in addition to measuring blood glucose levels, you should measure HbA1c (average blood glucose over 2-3 months) and insulin levels. Insulin, remember, is your blood sugar boss. So watching the insulin response following an oral glucose tolerance test (OGTT) can give a real insight into your metabolic flexibility. Often, a hyperinsulinemic (high insulin) response to glucose is a harbinger for Type 2 Diabetes. 

Managing Your Blood Glucose

Here are some proven strategies for keeping blood sugar within a healthy range:

    • Exercise: Exercise increases insulin sensitivity, the opposite of insulin resistance. Both endurance exercise and weight training have been shown to have positive effects.
    • Fasting: Nothing lowers blood glucose and insulin levels like not eating. Start with 16-hour intermittent fasts, and work your way up as comfort and schedule permit.
    • The keto diet: The ketogenic diet severely limits carbs, helping minimize the blood sugar response. (Carbs are sugar, after all).
    • Measure your blood glucose: Knowing how blood sugar fluctuates with different foods helps you make smarter choices.
    • Spice and supplement: Spice your food with turmeric and cinnamon – or consider supplementing berberine – to limit your blood sugar response.
    • Sleep well: Sleep is crucial for insulin function. Prioritize it.

The Relationship Between Glucose and Ketones

Glucose and ketones tend to be inversely related. As glucose rises, ketones fall. But blood sugar responds more quickly to the introduction of foods than ketones do, which is why measuring glucose on a ketogenic diet is so important in sleuthing out foods that will adversely impact ketosis.

The Final Word

If you aren’t tracking your blood glucose, now’s the time to start. Along with other tests, it gives you an important picture of your metabolic health. 

Optimal fasting blood glucose levels are likely between 70 mg/dl and 85 mg/dl (3.9 and 4.7 mmol/L). Higher, and diabetes risk goes up. Lower, and you risk a low blood sugar state called hypoglycemia. 

Measuring blood glucose is easy. You need only a glucometer and test strips. It’s an excellent tool to identify the foods that cause an elevated response in blood sugar in your body so you can adjust your diet accordingly.  

To keep your blood sugar under control, be sure to exercise, sleep, and avoid carb binging. To really kick it up a notch, consider keto or intermittent fasting. All these strategies enhance the function of insulin, which in turn improves your blood sugar response.

Check out this video with Thomas DeLauer for more on insulin resistance. Also, measure your GKI, which provides a more bird’s eye-view of metabolic health. 

 

References

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