79 Summaries
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Endocrine, CancerThe genetically predicted causal associations between circulating 3-hydroxybutyrate levels and malignant neoplasms: A pan-cancer Mendelian randomization study
Emerging research suggests that β-hydroxybutyrate (BHB), a ketone body produced via hepatic fatty acid β-oxidation, may have protective effects against certain cancers. This study aimed...
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Cardiovascular DiseaseKetosis prevents abdominal aortic aneurysm rupture through C–C chemokine receptor type 2 downregulation and enhanced extracellular matrix balance
Abdominal aortic aneurysms (AAAs) are a serious condition often linked to aging, with rupture leading to high mortality rates. Currently, there is no effective medical...
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General HealthNutrient analysis of three low-carbohydrate diets differing in carbohydrate content
Low-carbohydrate diets have proven effective in managing conditions like type 2 diabetes, polycystic ovarian syndrome, and obesity. However, there are concerns about their effects on...
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Epilepsy, NeurologyShort-term effectiveness and side effects of ketogenic diet for drug-resistant epilepsy in children with genetic epilepsy syndromes
Drug-resistant epilepsy (DRE) affects approximately one-third of all epilepsy patients and is defined by the failure of two or more anti-seizure medications to control seizures. Surgical or...
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Diabetes5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study
Over the past two decades, research has challenged the view that type 2 diabetes is an irreversible, progressive condition. New evidence suggests that sustained remission,...
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General Health, NeurologyImpact of a ketogenic diet on sleep quality in people with relapsing multiple sclerosis
Multiple sclerosis (MS) is a neurodegenerative disease that can cause various symptoms, including sleep disturbances, which affect up to 50% of individuals with the condition....
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Musculoskeletal, Neurology, Metabolic SyndromeKetone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding
Intermittent fasting (IF) and time-restricted feeding (TRF) are dietary regimens known to produce favorable metabolic outcomes. During periods of fasting, ketones are well-recognized as an...
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CancerTargeting fatty acid oxidation enhances response to HER2-targeted therapy
In a recent article in Nature Communications, the authors explore the complexity of metabolic reprogramming in ErbB2+ breast cancer models, in vitro and in vivo....
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DiabetesProlonged remission followed by low insulin requirements in a patient with type 1 diabetes on a very low-carbohydrate diet
While insulin therapy has dramatically improved life expectancy for people with type 1 diabetes (T1D), blood sugar control remains challenging. For this reason, there has...
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