Very Low-Carbohydrate Ketogenic Diet in Treatment-Naïve Women with Endometrial Cancer and Overweight: A Randomized Feasibility Study

Endometrial cancer is strongly associated with obesity, insulin resistance, and hyperinsulinemia. More than 90% of endometrial tumors contain alterations in the PI3K signaling pathway, which...

Postoperative recurrence of pancreatic cancer controlled for 9 months solely by severe carbohydrate restriction: ketogenic diet

This case report documents the experience of a 60-year-old female patient with pancreatic ductal adenocarcinoma (PDAC), whose metastatic recurrence was stabilized for nine months through...

Ketogenic diet as a metabolic vehicle enhancing the therapeutic efficacy of mebendazole and devimistat in juvenile syngeneic high-grade glioma  

Pediatric high-grade gliomas (HGGs) are aggressive brain tumors with poor outcomes and substantial treatment-related toxicity. Because glioma cells rely heavily on glucose and glutamine metabolism,...

The glucose ketone index: a proposed quantitative biomarker to support cancer and chronic disease prevention and management 

Mitochondrial dysfunction is increasingly recognized as a common feature of many chronic diseases, including cancer, type 2 diabetes, cardiovascular disease, obesity, neurodegenerative disorders, and some...

Intensive Multimodal Ketogenic Metabolic Therapy in Glioblastoma: A Clinical Trial

Glioblastoma (GBM), isocitrate dehydrogenase (IDH)-wildtype, is the most common and aggressive primary brain tumor in adults, with a median overall survival of approximately 11–14 months...

Targeting differential energy substrate metabolism on a therapeutic ketogenic diet: a case report

This case report examines the relationship between exercise intensity and blood ketone levels in a 44-year-old male patient with glioblastoma who followed a therapeutic ketogenic...

A randomized phase II trial of gemcitabine, nab‐paclitaxel, cisplatin with or without a medically supervised ketogenic diet for patients with metastatic pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with limited treatment options, particularly in the metastatic setting. Interest has grown in metabolic therapies such...

Ketosis suppression and ageing (KetoSAge): the effect of suppressing ketosis on SHBG and sex hormone profiles in healthy premenopausal women, and its implications for cancer risk and therapy

This secondary analysis of the KetoSAge study examined how short-term suppression of nutritional ketosis affects sex hormone-binding globulin (SHBG) and related metabolic markers in healthy,...

Critical Review of Ketogenic Diet Throughout the Cancer Continuum for Neuroglioma: Insights from a Medical Nutrition Therapy (MNT) Perspective

The ketogenic diet has gained attention as a potential adjunct therapy for neurogliomas, including glioblastoma and astrocytoma. These aggressive brain tumors have low survival rates,...

Safety, Feasibility, and Effectiveness of Ketogenic Diet in Pediatric Patients with Brain Tumors: A Systematic Review

Researchers conducted a systematic review to assess the safety, feasibility, and potential effectiveness of a ketogenic diet in pediatric patients with brain tumors. The review included eight...

A phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for patients with recently diagnosed glioblastoma

A phase 1, single-arm clinical trial investigated the safety and feasibility of implementing a ketogenic diet (KD) alongside standard-of-care chemoradiation in patients with newly diagnosed glioblastoma (GBM), a highly aggressive brain...

The genetically predicted causal associations between circulating 3-hydroxybutyrate levels and malignant neoplasms: A pan-cancer Mendelian randomization study

Emerging research suggests that β-hydroxybutyrate (BHB), a ketone body produced via hepatic fatty acid β-oxidation, may have protective effects against certain cancers. This study aimed...

Targeting fatty acid oxidation enhances response to HER2-targeted therapy

In a recent article in Nature Communications, the authors explore the complexity of metabolic reprogramming in ErbB2+ breast cancer models, in vitro and in vivo....

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma

Glioblastoma (GBM) is a highly aggressive brain tumor with limited effective treatment options. Despite the known role of glucose and glutamine in fueling GBM growth,...

Systematic Review and Clinical Insights: The Role of the Ketogenic Diet in Managing Glioblastoma in Cancer Neuroscience

Glioblastoma (GBM) is the most common and aggressive primary central nervous system tumor, and it has a very poor prognosis. Despite advancements in treatments such...

Ketogenic metabolic therapy in conjunction with standard treatment for glioblastoma: a case report

Glioblastoma (GBM) is a highly aggressive brain tumor with a median survival rate of 12 to 15 months under standard care, which includes surgery, radiation,...

Triple Therapy with Metformin, Ketogenic Diet, and Metronomic Cyclophosphamide Reduced Tumor Growth in MYCN-Amplified Neuroblastoma Xenografts

In a recent article in Metabolites, scientists are investigating new ways to tackle neuroblastoma, a serious type of childhood cancer connected to changes in the...

Feasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial

Metastatic breast cancer is a challenging diagnosis with a limited number of therapeutic options. A high-fat, moderate protein, very low-carbohydrate ketogenic diet has received attention...

Current knowledges in pharmaconutrition: "Ketogenics" in pediatric gliomas

Brain tumors constitute 20-25% of pediatric cancers, with Glioma being the most common. Current treatments, which include chemotherapy and surgery, have severe side effects. This...