A phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for patients with recently diagnosed glioblastoma
A phase 1, single-arm clinical trial investigated the safety and feasibility of implementing a ketogenic diet (KD) alongside standard-of-care chemoradiation in patients with newly diagnosed glioblastoma (GBM), a highly aggressive brain...
The genetically predicted causal associations between circulating 3-hydroxybutyrate levels and malignant neoplasms: A pan-cancer Mendelian randomization study
Emerging research suggests that β-hydroxybutyrate (BHB), a ketone body produced via hepatic fatty acid β-oxidation, may have protective effects against certain cancers. This study aimed...
Targeting fatty acid oxidation enhances response to HER2-targeted therapy
In a recent article in Nature Communications, the authors explore the complexity of metabolic reprogramming in ErbB2+ breast cancer models, in vitro and in vivo....
Systematic Review and Clinical Insights: The Role of the Ketogenic Diet in Managing Glioblastoma in Cancer Neuroscience
Glioblastoma (GBM) is the most common and aggressive primary central nervous system tumor, and it has a very poor prognosis. Despite advancements in treatments such...
Triple Therapy with Metformin, Ketogenic Diet, and Metronomic Cyclophosphamide Reduced Tumor Growth in MYCN-Amplified Neuroblastoma Xenografts
In a recent article in Metabolites, scientists are investigating new ways to tackle neuroblastoma, a serious type of childhood cancer connected to changes in the...
Feasibility and metabolic outcomes of a well-formulated ketogenic diet as an adjuvant therapeutic intervention for women with stage IV metastatic breast cancer: The Keto-CARE trial
Metastatic breast cancer is a challenging diagnosis with a limited number of therapeutic options. A high-fat, moderate protein, very low-carbohydrate ketogenic diet has received attention...
Current knowledges in pharmaconutrition: "Ketogenics" in pediatric gliomas
Brain tumors constitute 20-25% of pediatric cancers, with Glioma being the most common. Current treatments, which include chemotherapy and surgery, have severe side effects. This...
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