80 Summaries
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General HealthRenNu, a Dietary Program for Individuals with Autosomal-Dominant Polycystic Kidney Disease Implementing a Sustainable, Plant-Focused, Kidney-Safe, Ketogenic Approach with Avoidance of Renal Stressors
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited cause of kidney failure, with limited treatment options available that do not achieve regression. Recent...
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Cancer, Endocrine
The genetically predicted causal associations between circulating 3-hydroxybutyrate levels and malignant neoplasms: A pan-cancer Mendelian randomization study
Emerging research suggests that β-hydroxybutyrate (BHB), a ketone body produced via hepatic fatty acid β-oxidation, may have protective effects against certain cancers. This study aimed...
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Cardiovascular Disease
Ketosis prevents abdominal aortic aneurysm rupture through C–C chemokine receptor type 2 downregulation and enhanced extracellular matrix balance
Abdominal aortic aneurysms (AAAs) are a serious condition often linked to aging, with rupture leading to high mortality rates. Currently, there is no effective medical...
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General Health
Nutrient analysis of three low-carbohydrate diets differing in carbohydrate content
Low-carbohydrate diets have proven effective in managing conditions like type 2 diabetes, polycystic ovarian syndrome, and obesity. However, there are concerns about their effects on...
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Epilepsy, Neurology
Short-term effectiveness and side effects of ketogenic diet for drug-resistant epilepsy in children with genetic epilepsy syndromes
Drug-resistant epilepsy (DRE) affects approximately one-third of all epilepsy patients and is defined by the failure of two or more anti-seizure medications to control seizures. Surgical or...
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Diabetes
5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study
Over the past two decades, research has challenged the view that type 2 diabetes is an irreversible, progressive condition. New evidence suggests that sustained remission,...
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General Health, Neurology
Impact of a ketogenic diet on sleep quality in people with relapsing multiple sclerosis
Multiple sclerosis (MS) is a neurodegenerative disease that can cause various symptoms, including sleep disturbances, which affect up to 50% of individuals with the condition....
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Musculoskeletal, Neurology, Metabolic Syndrome
Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding
Intermittent fasting (IF) and time-restricted feeding (TRF) are dietary regimens known to produce favorable metabolic outcomes. During periods of fasting, ketones are well-recognized as an...
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Cancer
Targeting fatty acid oxidation enhances response to HER2-targeted therapy
In a recent article in Nature Communications, the authors explore the complexity of metabolic reprogramming in ErbB2+ breast cancer models, in vitro and in vivo....
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